CHROMATOGRAPHIC METHOD OF SEPARATION OF RADIONUCLIDE LUTETIUM-177, CARRIER FREE FROM MACRO-QUANTITIES OF YTTERBIUM

Akhmedov Zh. A; Usarov Z. O; Abdukayumov A. M; Rikhsiev A. Z; Sherov O. O

doi:10.17605/OSF.IO/AG2D8

Authors

Akhmedov Zh. A State Enterprise "Radiopreparat" INP AS RUz, Tashkent
Usarov Z. O State Enterprise "Radiopreparat" INP AS RUz, Tashkent
Abdukayumov A. M State Enterprise "Radiopreparat" INP AS RUz, Tashkent
Rikhsiev A. Z State Enterprise "Radiopreparat" INP AS RUz, Tashkent
Sherov O. O State Enterprise "Radiopreparat" INP AS RUz, Tashkent

DOI:

https://doi.org/10.17605/OSF.IO/AG2D8

Keywords:

lutetium, ytterbium, carrier free, half-life, isotop, separation, radionuclide, Chromatographic method, irradiating, thermal neutron, nuclear reactor, nuclear reaction, ion-exchange resin, chromatographic column, HPLC, gradient.

Abstract

Currently, promising direction of development of modern oncology is a radionuclide therapy using radiopharmaceuticals sighting direction, ie the targeted effect on tumor tissue. For this purpose, suitable radionuclide ¹⁷⁷Lu, possessing optimal nuclear-physical characteristics with an average half-life (T_1/2 = 6,7 days); acceptable energy β-particles (maximum 0,5 MeV), which allows to destroy small tumors and metastasis without affecting the healthy tissues; concomitant soft γ-radiation with sufficient energy for imaging. Targeted exposure helps to get rid of neuroendocrine tumors, thyroid cancers, some types of brain cancer, and prostate cancer, and so on.

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References

SNMMI/NCI Third Targeted Radionuclide Therapy Conference 2019 Monday, December 16, 2019, National Cancer Institute – Shady Grove, Maryland

Louise Emmett, Kathy Willowson, John Violet, Jane Shin, Ashley Blanksby, Jonathan Lee. Lutetium 177 PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy. – J. Med. Radiat. Sci. 2017, 64(1), Р. 52-60.

Кодина Г.Е., Красикова Р.Н. Методы получения радиофар м ацев тиче ских препара т ов и радио -нуклидных генераторов для ядерной медицины. М., 2014. С. 60.

В.А. Тарасов, Е.Г. Романов, Р.А. Кузнецов. СРАВНИТЕЛЬНЫЙ АНАЛИЗ СХЕМ РЕАКТОРНОЙ НАРАБОТКИ ЛЮТЕЦИЯ-177. Известия Самарского научного центра Российской академии наук, 2013, т. 15, №4(5), С. 1084-1090.

Отчет НИР Института Ядерной Физики Академии Наук Республики Узбекистан. № Гос рег. 01.2000.09698, Ташкент 2002, 40 с.